Table 3.
Provocation/re-exposure of ICM in patients with a non-immediate hypersensitivity reaction (NIHR) (n = 10 studies).
| Study | Study design | N (NIHR) | (Delayed) Positive SPT and/or IDT or patch test (%) | Culprit skin test negative |
Culprit skin test positive |
Premedication administered prior to
provocation or re-exposure |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Positive provocation test or re-exposure reaction to culprit or skin test negative alternative ICM (%) | Negative predictive value | Positive provocation test or exposure reaction to skin test negative ICM (%) | Negative predictive value | Positive provocation test or exposure reaction to skin test positive ICM (%) | Positive predictive value | |||||
| Vernassiere et al.53 | R, I | 15 | 8/15 (53.3) | 2/7 (28.6) | 0.71 | 3/8 (37.5) | 0.625 | – | NA | None |
| Seitz et al. 25 | R, I | 32 | 6/32 (18.8) | – | NA | 0/4 (0) | 1 | – | NA | None |
| Caimmi et al.54 | R | 17 | 3/17 (42.9) | 1/4 (25) | 0.75 | – | NA | – | NA | None |
| Torres et al. 29 | P, I | 161 | 34/161 (21.1) | 44/127 (34.6) | 0.65 | 11/34 (32.4) | 0.68 | – | NA | None |
| Ahn et al. 21 | P | 6 | 3/6 (50) | – | NA | 0/1 (0) | 1 | – | NA | In all |
| Della-Torre et al. 31 | R | 17 | 5/17 (29.4) | 0/12 (0) | 1 | 0/5 (0) | 1 | – | NA | In all |
| Schrijvers et al. 18 | R | 118 | 20/118 (16.9) | 5/37(12.8) a | 0.86 | 0/4 a (0) | 1 | 1/2 a (50) | 0.5 | In 20.7% |
| Trautmann et al. 26 | R | 13 | 13/13 (100) | – | NA | 0/8 (0) | 1 | – | NA | None |
| Meucci et al. 33 | R | 16 | 3/16 (18.8 ) | 4/13 (30.8) | 0.69 | 2/2 (100) | 0 | 1/1 (100) | 1 | None |
| Dona et al. 34 | P | 89 | 39/89 (43.8) | 50/50 (100) b | 0 | 14/39 (35.9) | 0.64 | – | NA | None |
N: number of patients; P: prospective; R: retrospective; NA: not applicable.
a
Five patients had a positive skin test. One with NIHR and positive skin tests and with a positive reaction upon provocation was excluded due to the provocation with an unknown ICM.
b
Patients with a proven ICM allergy, based on clinical history, skin tests and drug provocation tests, were evaluated for an allergy to other ICM.