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. 2021 May 19;12:644862. doi: 10.3389/fimmu.2021.644862

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Copyright © 2021 Wang, Zhou, Zou, Chen, Huang, Yang, Pan, Xu, Xu, Chen, Chen, Gong, Zhou, Xu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the 'copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MCT4 regulated ERK1/2-NF-κB pathway. (A) Western blotting was employed to test phosphorylation of NF-κB and ERK1/2 activity in HT-29 and CaCO2 cells. (B) The total protein was collected in HT-29 and CaCO2 cells with or without α-CHCA stimulation for 1 h, and the indicated proteins was tested by immunoblotting. The ERK1/2 inhibitor U0126 and NF-κB inhibitor BAY11-7085 were used to treat CaCO2 cells with MCT4 overexpression for 48 h. Western blotting (C) and ELISA (D) were used to analyze IL-1β expression and secretion, respectively. Data represented the mean ± s.d. of three independent experiments; one-way ANOVA was performed to analyze statistical difference. ***p < 0.001.