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. 2021 May 19;11:671333. doi: 10.3389/fonc.2021.671333

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Copyright © 2021 Li, Shi, Liu, Fang, Cao, Meng, Zhang, Yu, Feng, Li, Liu, Wang, Jiang, Lu, Shao and Bian

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison between patients with low and high CD8⁺ T-cell infiltration (A–C) Patient 1: A 65-year-old man with PDAC in the CD8⁺ T-high group. (A) CD8⁺ T-cell infiltration is high (×20). (B) The axial portal-phase CT image shows an infiltrative, low-attenuation mass (arrows) located at the pancreatic head. (C) The prediction probability of low CD8⁺ T infiltration was 80.58% by XGBoost classifier. (D–F) Patient 2: A case of a 49-year-old man with PDAC in the CD8⁺ T-low group. (D) CD8⁺ T-cell infiltration is low (×20). (E) The axial portal-phase CT image shows an infiltrative, low-attenuation mass (arrows) located at the pancreatic body and tail. (F) The prediction probability of low CD8⁺ T-cell infiltration is 70.07% by XGBoost classifier.