Table 2.

Studies of cost-effectiveness of therapies for Clostridiodes difficile infection.

Study no.	Author	Country	Year of publication	CDI episode	Treatment regimens compared	Most cost-effective treatment
Initial C. difficile infection
1	Stranges et al. 77	US	2013	Initial	Vancomycin versus fidaxomicin	Fidaxomicin for mild-moderate CDI Vancomycin for severe CDI
2	Varier et al. 78	US	2014	Initial	Vancomycin versus metronidazole versus FMT	FMT
3	Wagner et al. 79	Canada	2014	Initial	Vancomycin versus fidaxomicin	Vancomycin
4	Nathwani et al. 80	UK	2014	Initial	Vancomycin versus fidaxomicin	Fidaxomicin
5	Marković et al. 81	Serbia	2014	Initial	Vancomycin versus fidaxomicin	Fidaxomicin
6	Rubio-Terres et al. 82	Spain	2015	Initial	Vancomycin versus extended-pulsed fidaxomicin	Extended-pulsed fidaxomicin
7	Watt et al. 83	Germany	2016	Initial	Vancomycin versus fidaxomicin	Fidaxomicin
8	Watt et al. 84	France	2017	Initial	Vancomycin versus fidaxomicin	Fidaxomicin
9	Rajasingham et al. 75	US	2020	Initial	Vancomycin versus fidaxomicin versus metronidazole	Fidaxomicin for non-severe CDI Vancomycin for severe CDI
Recurrent C. difficile infection
1	Konijeti et al. 85	US	2014	Recurrent	Vancomycin versus fidaxomicin versus metronidazole versus FMT	FMT by colonoscopy
2	Zowall et al. 86	Canada	2014	Recurrent	Standard antibiotic regimens versus FMT	FMT
3	Varier et al. 87	US	2015	Recurrent	Tapered vancomycin versus FMT	FMT
4	Lapointe-Shaw et al. 88	Canada	2016	Recurrent	Vancomycin versus fidaxomicin versus metronidazole versus FMT by enema versus FMT by colonoscopy versus FMT by NGT	FMT by colonoscopy
5	Merlo et al. 89	Australia	2016	Recurrent	Vancomycin versus FMT	FMT
6	Waye et al. 90	Canada	2016	Recurrent	Early FMT versus Delayed FMT	Early FMT
7	Baro et al. 91	France	2017	Recurrent	Pulse-tapered vancomycin versus fidaxomicin versus FMT	FMT by enema
8	Prabhu et al. 92	US, UK	2017	Recurrent	Bezlotuxumab versus placebo	Bezlotuxumab
9	Jiang et al. 93	China	2018	Recurrent	Vancomycin versus ribotype-guided FMT	Ribotype-guided FMT
10	Abdali et al. 94	UK	2020	Recurrent	Vancomycin versus fidaxomicin versus FMT	FMT by NGT
11	Rajasingham et al. 75	US	2020	Recurrent	Vancomycin versus fidaxomicin versus metronidazole versus FMT	Fidaxomicin for first recurrence FMT for subsequent recurrences
12	You et al. 95	China	2020	Recurrent CDI in IBD patients	Vancomycin versus fidaxomicin versus vancomycin plus bezlotuxumuab versus FMT	FMT

CDI, Clostridiodes difficile infection; FMT, fecal microbiota transplantation; IBD, inflammatory bowel disease; NGT, nasogastric tube.