Table 2.
Compressive optic neuropathy response to teprotumumab.
| Case | Laterality of CON | RAPD | Resolution of RAPD | VA OD/OS Pre Infusion | VA OD/OS Post Infusion | Color vision deficit | Normalization of color vision |
|---|---|---|---|---|---|---|---|
| 1 | OU | No | n/a | HM | 20/800 | n/aa | n/a |
| HM | 20/800 | ||||||
| 2 | OU | No | n/a | HM | 20/800 | n/aa | n/a |
| HM | 20/800 | ||||||
| 3 | OU | No | n/a | 20/200 | 20/50 | OU | Yes |
| 20/200 | 20/30 | ||||||
| 4 | OS | No | n/a | 20/30 | 20/20 | OS | Yes |
| 20/30 | 20/20 | ||||||
| 5 | OU (OS > OD) | OS | Yes | 20/40 | 20/20 | OS | Yes |
| 20/125 | 20/20 | ||||||
| 6 | OS | OS | Yes | 20/25 | 20/25 | OS | Yes |
| 20/100 | 20/25 | ||||||
| 7 | OD | OD | Yes | 20/25 | 20/20 | n/ab | n/a |
| 20/25 | 20/20 | ||||||
| 8 | OU (OS > OD) | OS | Yes | 20/100 | 20/25 | OU | Yes |
| 20/60 | 20/30 | ||||||
| 9 | OS | OS | Yes | 20/30 | 20/20 | OS | Yes |
| 20/40 | 20/20 | ||||||
| 10 | OU (OS > OD) | OS | Noc | 20/100 | 20/70 | OD | Nod |
| HM | 20/200 |
CON = compressive optic neuropathy, HM = hand motion, OD = right eye, OS = left eye, OU = both eyes, RAPD = relative afferent pupillary defect, VA = visual acuity.
a
VA too poor to evaluate color vision.
b
Congenital color blindness.
c
Improvement of RAPD.
d
Improvement of color vision from 0/11 to 3/11 OU.