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. 2021 May 19;11:661431. doi: 10.3389/fonc.2021.661431

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Copyright © 2021 Jiang, Deng, Zhu, Zeng, Hu, Zhou, Xie, Zhang, Fu, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LINC00467 downregulation inhibits cell growth, cell cycle progression, migration, and infiltration. (A) RT-qPCR assessment of LINC00467 expression levels in DU145 and 22RV1 cells after transfection with siLINC00467 or the negative control. (B, D) CCK-8 and EdU assay data indicating proliferation of DU145 and 22RV1 cells transfected with siLINC00467 or the negative control. (E, F) Cell cycle progression results indicating that DU145 and 22RV1 cells were arrested in the G0/G1 phase after treatment with siLINC00467. (G, H) Cell migration and invasion results indicating that the downregulation of LINC00467 expression inhibits the migration and invasion of DU145 and 22RV1 cells. (I) Western blot analysis showed that the EMT protein was decreased after treatment with siLINC00467. ***p < 0.001, ****p < 0.0001; the data are presented as the means ± SD, n = 3.