Figure 5.

miR-494-3p inhibits prostate cancer progression by targeting STAT3. (A, C) RT-qPCR indicating that miR-494-3p expression was downregulated in PC tissues and cell lines compared to nonmalignant tissues and cell lines. (B) A negative correlation between the expression of LINC00467 and miR-494-3p was showed using Spearman correlation analysis. (D, E) RT-qPCR was used to assess the efficiency of the miR-494-3p inhibitor and mimic in PC cells. (F–H) CCK-8 and Transwell assays showing that the miR-494-3p mimic repressed the proliferation, migration and invasion of 22RV1 cells. (I–K) CCK-8 and Transwell assays indicating that the miR-494-3p inhibitor promoted the proliferation, migration and invasion of DU145 cells, which could be reversed by siSTAT3. **p < 0.01, ***p < 0.001; the data are presented as the means ± SD, n = 3.