Table 1.
Functional characteristics of Nav1.2 channel.
| Peak amplitude of Na+ current | Voltage dependence of activation | Voltage dependence of fast inactivation | Recovery from fast inactivation | ||||
|---|---|---|---|---|---|---|---|
| pA/pF | V0.5 (mV) | k (mV) | V0.5 (mV) | k (mV) | τ1 (ms) | τ2 (ms) | |
| WT | −613.85 ± 38.72 | −20.59 ± 0.83 | 6.84 ± 0.64 | −59.67 ± 1.65 | 5.91 ± 0.84 | 1.42 ± 0.11 | 37.58 ± 8.62 |
| S863F | −305.53 ± 65.15** | −20.80 ± 0.88* | 6.60 ± 0.69 | −65.0 ± 0.95** | 9.07 ± 0.61** | 1.85 ± 0.08** | 41.30 ± 8.11 |
| V911A | −793.23 ± 68.67* | −24.8 ± 0.91** | 6.22 ± 0.55 | −61.05 ± 0.74 | 5.73 ± 0.50 | 1.04 ± 0.08* | 33.54 ± 6.02 |
| I1571T | −572.07 ± 104.75 | −27.57 ± 1.82** | 6.70 ± 0.72 | −59.60 ± 1.30 | 4.93 ± 0.47 | 0.61 ± 0.15** | 25.02 ± 6.14** |
V0.5 is voltage of half-maximal (in-)activation; k is slope factor; τ is time constant. Data are presented as means ± SEM, n = 12–15.
*
p < 0.05 and
**
p < 0.01 vs. WT were determined by a Dunnett's post-hoc test after a one-way ANOVA.