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. 2021 May 25;15:100347. doi: 10.1016/j.ynstr.2021.100347

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 5 — Subnetwork analysis. (A, B and C) Phenotype-associated (subnetwork-P1, -P2 and -P3) and drug-associated (subnetwork-D1, -D2 and -D3) lncRNA-mRNA subnetworks were compared and analyzed, respectively. Subnetworks were constructed using the CytoHubba plugin. Advanced ranking of hub genes is represented by redder color. (D) Potential network of drug-lncRNA-mRNA-phenotype. Thirty-six anti-depression/anxiety drugs potentially act on 16 target lncRNAs to affect expression of the correlated 20 mRNAs. These lncRNAs and mRNAs were differentially expressed in the depression-susceptible (Dep-Sus), anxiety-susceptible (Anx-Sus) and insusceptible (Insus) groups. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)