. 2021 Jun 2;19:39. doi: 10.1186/s12959-021-00293-8

Table 3.

Rotem® and Multiplate® results in ICU patients (total n = 18)

Parameters	day 1	day 4	day 7	day 14
Rotem® INTEM CT [s] (100–240) CFT [s] (30–110) A10 [mm] (44–66) MCF [mm] (50–72) LI30 [%] (94–100)	207 (180–292) 62 (44–75) 70 (61–75) 75 (66–79) 100 (99–100)	273 (206–366) 59 (42–108) 69 (64–75) 75 (72–79) 100 (99–100)	242 (203–297) 45 (41–76) 71 (65–76) 77 (70–79) 100 (100–100)	229 (186–326) 43 (36–59) 72 (67–77) 76 (72–82) 100 (100–100)
Rotem® EXTEM CT [s] (38–79) CFT [s] (34–159) A10 [mm] (43–65) MCF [mm] (50–72) LI30 [%] (94–100)	85 (77–97) 48 (43–59) 70 (62–76) 76 (71–80) 100 (99–100)	87 (73–98) 49 (39–69) 70 (65–75) 76 (72–78) 100 (100–100)	79 (70–85) 39 (35–61) 71 (66–77) 76 (72–80) 100 (100–100)	79 (71–84) 37 (27–56) 72 (67–77) 77 (73–81) 100 (99–100)
Rotem® FIBTEM A10 [mm] (7–23) MCF [mm] (9–25)	38 (31–42) 39 (35–45)	42 (32–52) 46 (36–54)	45 (34–55) 51 (36–61)	43 (31–52) 45 (33–53)
Rotem® Delta ∆A10 (EXTEM minus FIBTEM) [mm] ∆MCF (EXTEM minus FIBTEM) [mm]	33 (27–36) 36 (29–37)	24 (19–35) 29 (22–36)	29 (23–33) 28 (23–35)	30 (24–36) 33 (25–40)
Multiplate® TRAP-6 [AUC] (941–1563) ADP [AUC] (534–1220) ASPI [AUC] (745–1361)	518 (241–819) 277 (155–410) 378 (116–800)	430 (279–676) 287 (181–401) 365 (126–673)	367 (236–744) 214 (154–332) 289 (95–797)	555 (276–809) 402 (166–586) 461 (184–1317)

Parameters

day 1

day 4

day 7

day 14

Rotem® INTEM

CT [s] (100–240)

CFT [s] (30–110)

A10 [mm] (44–66)

MCF [mm] (50–72)

LI30 [%] (94–100)

207 (180–292)

62 (44–75)

70 (61–75)

75 (66–79)

100 (99–100)

273 (206–366)

59 (42–108)

69 (64–75)

75 (72–79)

100 (99–100)

242 (203–297)

45 (41–76)

71 (65–76)

77 (70–79)

100 (100–100)

229 (186–326)

43 (36–59)

72 (67–77)

76 (72–82)

100 (100–100)

Rotem® EXTEM

CT [s] (38–79)

CFT [s] (34–159)

A10 [mm] (43–65)

MCF [mm] (50–72)

LI30 [%] (94–100)

85 (77–97)

48 (43–59)

70 (62–76)

76 (71–80)

100 (99–100)

87 (73–98)

49 (39–69)

70 (65–75)

76 (72–78)

100 (100–100)

79 (70–85)

39 (35–61)

71 (66–77)

76 (72–80)

100 (100–100)

79 (71–84)

37 (27–56)

72 (67–77)

77 (73–81)

100 (99–100)

Rotem® FIBTEM

A10 [mm] (7–23)

MCF [mm] (9–25)

38 (31–42)

39 (35–45)

42 (32–52)

46 (36–54)

45 (34–55)

51 (36–61)

43 (31–52)

45 (33–53)

Rotem® Delta

∆A10 (EXTEM minus FIBTEM) [mm]

∆MCF (EXTEM minus FIBTEM) [mm]

33 (27–36)

36 (29–37)

24 (19–35)

29 (22–36)

29 (23–33)

28 (23–35)

30 (24–36)

33 (25–40)

Multiplate®

TRAP-6 [AUC] (941–1563)

ADP [AUC] (534–1220)

ASPI [AUC] (745–1361)

518 (241–819)

277 (155–410)

378 (116–800)

430 (279–676)

287 (181–401)

365 (126–673)

367 (236–744)

214 (154–332)

289 (95–797)

555 (276–809)

402 (166–586)

461 (184–1317)

Rotem® and Multiplate® results at days 1, 4, 7 and 14 after admission to ICU (total n = 18).

Point-of-Care testing over the course of ICU treatment. Rotem® results are shown for INTEM, EXTEM, FIBTEM and Delta (EXTEM minus FIBTEM). HEPTEM data are not depicted. Multiplate® results are displayed for the agonists thrombin receptor activator peptide 6 (TRAP-6), adenosine diphosphate (ADP) and arachidonic acid (ASPI) as Area under the Curve (AUC), respectively. Values are expressed as median and IQR. Units are displayed in square brackets and reference values in round brackets. Abbreviations: CT Clotting Time, CFT Clot Formation Time, A10 Amplitude 10 min after CT, MCF Maximum Clot Firmness, LI30 Lysis Index 30 min.