Figure 6.

Gene and protein expression levels of p97 in urothelial carcinoma

(A) TCGA p97 gene expression levels across different cancer types, comparing tumor expression levels (shown as red dots) to normal tissue (shown as green dots). Bladder cancer is abbreviated “BLCA.” Tumor abbreviations in red have a statistically significant increase in p97 gene expression compared to normal tissues, whereas abbreviations in green have higher levels of p97 gene expression in normal tissues. Abbreviations in black show no statistically significant effect.

(B) Disease-specific survival analysis of p97 gene expression; log-rank test, ^∗p = 0.05.

(C) Representative images of two tumor cases from a total of 27 patients with urothelial carcinoma stained with p97 antibody. Each vertical tile represents a separate case (marked as “I” and “II”). The invasive and papillary areas show the highest and the lowest nuclear staining intensity, respectively.

(D) Cytoplasmic and nuclear p97 H-scores in papillary and invasive regions are shown. Data are presented as mean H-score ± SEM. Mann-Whitney U test: ^∗∗p < 0.01 and ^∗∗∗∗p < 0.0001.