. 2021 May 19;15:665386. doi: 10.3389/fncir.2021.665386

TABLE 6.

Negative valence systems.

Paradigm	Manipulation	Behavioral Result	Citation
*Construct: Acute threat (“Fear”)*
Elevated plus maze	DAT^Cre;VGluT2^flox/flox	Increased latency to start	Birgner et al., 2010
	TH^IRES–Cre;VGluT2^flox/flox	Normal	Nordenankar et al., 2015
	DAT^IRES–Cre;Gls1^flox/+	Normal	Mingote et al., 2017
	DAT^IRES–Cre;VGluT2^flox/flox	Increased anxiety after MPTP administration	Shen et al., 2018
Fear conditioning	DAT^IRES–Cre;Gls1^flox/+	Normal	Mingote et al., 2017
Open field test	DAT^Cre;VGluT2^flox/flox	Decreased time in the central circle of the open field	Birgner et al., 2010
	DAT^IRES–Cre;Gls1^flox/+	Normal	Mingote et al., 2017
*Construct: Sustained threat*
Forced swim test	DAT^Cre;VGluT2^flox/flox	Normal	Birgner et al., 2010
	DAT^Cre;VGluT2^flox/flox	Normal (though decreased latency to immobilization on Day 1)	Fortin et al., 2012
	TH^IRES–Cre;VGluT2^flox/flox	Normal	Nordenankar et al., 2015