. 2021 May 19;15:665386. doi: 10.3389/fncir.2021.665386

TABLE 7.

Motor control systems.

Paradigm	Manipulation	Behavioral Result	Citation
Locomotor activity	DAT^Cre;VGluT2^flox/flox	No difference in novelty-associated locomotion over 4 h or total locomotion across 3 days	Hnasko et al., 2010
	DAT^Cre;VGluT2^flox/flox	No difference in locomotion or rearing activity in novel environment; decreased horizontal activity	Fortin et al., 2012
	TH^IRES–Cre;VGluT2^flox/flox	Normal	Nordenankar et al., 2015
	DAT^IRES–Cre;Gls1^flox/+	Normal	Mingote et al., 2017
	Heterozygous VGluT2 over-expression unilateral SNc DAT^Cre	Significantly reduced spontaneous locomotor activity	Steinkellner et al., 2018
	DAT^IRES–Cre;VGluT2^flox/flox	MPTP induced a significant reduction in vertical activity. Viral rescue of VGluT2 in DA neurons attenuated these reductions.	Shen et al., 2018
Accelerating rotarod	DAT^Cre;VGluT2^flox/flox	Normal	Birgner et al., 2010
	DAT^Cre;VGluT2^flox/flox	Normal across 5 days	Hnasko et al., 2010
	DAT^Cre;VGluT2^flox/flox	Impaired (significant decrease in distance day 1, speed/latency to fall both days)	Fortin et al., 2012
	DAT^IRES–Cre;Gls1^flox/+	Normal across 3 days	Mingote et al., 2017
	DAT^IRES–Cre;VGluT2^flox/flox	No difference in MPTP-induced deficits	Shen et al., 2018
Beam walk	DAT^Cre;VGluT2^flox/flox	Normal	Birgner et al., 2010
Parallel rod floor	DAT^IRES–Cre;VGluT2^flox/flox	MPTP-induced deficits pronounced in cKO mice. Deficits were restored by viral rescue of VGluT2 expression in DA neurons.	Shen et al., 2018