Table 2.
Major phenotype of Nfe2l1 deficiency in specific tissue/cell.
| Target tissue/cell | Major phenotype | Genotype of mice/cells |
|---|---|---|
| Global | Embryonic lethality [60,61], | Nfe2l1-null |
| Oxidative stress ↑ [62,63], | ||
| Genetic instability [80] | ||
| Liver | Tumorigenesis ↑ [58,108] | Nfe2l1flox/flox; Alb-Cre+ |
| Lipid and amino acid metabolism ↓ [65] | ||
| Mitochondrial respiratory function ↓ [65] | ||
| Proteasome activity ↓ ER stress ↑ [64] | ||
| Macrophage | oxidative stress↑ [4] | /Nfe2l1-KD RAW264.7 cells |
| macrophage M1 polarization↑ [4] | ||
| Pancreatic β-cell | oxidative stress ↑ [16] | Nfe2l1flox/flox; Ins2-Cre+ |
| insulin secretion ↓ [16] | /Nfe2l1-KD MIN6 β-cells, | |
| tumorigenicity, aggressiveness, chemoresistance ↑ [109] | ||
| Osteoblast | osteoblast differentiation↓ [68] | Nfe2l1flox/flox; Col1α2-Cre+ |
| Neuronal cell | Proteasome activity ↓ [66,110] | Nfe2l1flox/flox; Camk2-Cre+ |
| Neurodegeneration [66,67,110]. | Nfe2l1flox/flox; Nestin-Cre+ | |
| Motor ataxia [67] | ||
| Chromatolysis [67] | ||
| Adipocyte | Lipolysis ↓ [13] | Nfe2l1flox/flox; Adipoq-Cre+ |
| Adipogenesis ↑ [11] adipocyte hypertrophy [13,14,98] | /Nfe2l1-KD 3T3-L1 cells | |
| inflammation [13,14,98] | ||
| Brown adipocyte | ER stress ↑ inflammation | Nfe2l1flox/flox; Ucp1-Cre+ |
| whitening [12] |