TABLE 1.

Definition of treatment effects on physiological parameters included in the Core Obesity Model

Surrogate outcomes	Treatment effect included in the model
BMI, kg/m2	BMI percentage change from baseline (note: percentage weight change in kg is equal to percentage BMI change)
SBP, mmHg	SBP absolute change from baseline
HDL cholesterol, mg/dL	HDL cholesterol absolute change from baseline
Total cholesterol, mg/dL	Total cholesterol absolute change from baseline
HbA1c, %, in diabetes	HbA1c percentage‐point change from baseline

Abbreviations: BMI, body mass index; HbA1c, glycated hemoglobin; HDL, high‐density lipoprotein; SBP, systolic blood pressure.