Figure 3.

Effect of Nar on myocardial oxidative stress in diabetic MI/R rats. Activities of (A) SOD and (B) GSH-Px, and the levels of (C) MDA, (D) 8-OHdG as well as (E) H₂O₂ formation in the myocardium were determined by spectrophotometry using commercially available kits. Data are presented as the mean ± SEM (number of repeated measurements: n=3/group). ^**P<0.01 and ^***P<0.001 compared with the STZ-sham group; ^#P<0.05, ^##P<0.01 and ^###P<0.001 compared with the STZ-M/IR group. GSH-Px, glutathione peroxidase; SOD, superoxide dismutase; MDA, malondialdehyde; 8-OHdG, 8-hydroxy-2 deoxyguanosine; STZ, streptozotocin; MI/R, myocardial ischemia reperfusion; Nar, naringenin.