Table 1.
Demographic characteristics of control and alcohol use disorder (AUD) subjects.
| Samples used for pSTAT3 IHC | Samples used for qPCR | ||||
|---|---|---|---|---|---|
| Subjects | Control | AUD | Control | AUD | AUD-BAL |
| n | 14 | 14 | 13 | 13 | 7 |
| Age | 61.6 ± 2.2 | 61.1 ± 2.4 | 57 ± 2 | 60 ± 1.8 | 49 ± 2.8# |
| Sex (n) | F (4), M (10) | F (4), M (10) | F (2), M (11) | F (4), M (9) | F (1), M (6) |
| PMI (h) | 34.4 ± 3.7 | 36.7 ± 3.8 | 35 ± 4.2 | 39 ± 5 | 40 ± 4.4 |
| pH | 6.6 ± 0.08 | 6.6 ± 0.06 | 6.6 ± 0.08 | 6.6 ± 0.08 | 6.7 ± 0.16 |
| BMI | 31.3 ± 1.7 | 25.8 ± 1.4* | 31 ± 1.5 | 25 ± 1.9 | 29 ± 2.0 |
| Total drinking years | 36.9 ± 3.3 | 35.9 ± 2.7 | 35 ± 3.1 | 38 ± 1.8 | 28 ± 3.2 |
| Ethanol daily use (g) | 17.5 ± 5.6 | 159.8 ± 32.6*** | 14 ± 4.9 | 179 ± 35** | 258 ± 73*** |
| Drinks per week | 10.9 ± 4.7 | 78.7 ± 18.2** | 8.5 ± 3.6 | 87 ± 19* | 147 ± 53** |
| Cigarette pack years | 16.9 ± 6.6 | 40.0 ± 7.3* | 25 ± 9.7 | 39 ± 5.1 | 30 ± 4.7 |
| Cause of death (n) | Cardiac (10), cancer (1), cardiovascular (1), respiratory (1), vascular (1) | Cardiac (8), hepatic (1), infection (2), respiratory (2), toxicity (1) | Cardiac (10), vascular (1), cardiovascular (1), toxicity (1) | Cardiac (6), respiratory (3), hepatic (1), toxicity (1), infection (1), stroke (1) | Cardiac (3), toxicity (3), unknown (1) |
Data are shown as mean ± SEM.
BMI body mass index, F female, M male, PMI postmortem interval (hours).
*p < 0.05, **p < 0.01, ***p < 0.001 by unpaired two-tailed Student’s t-test when compared to control. #p < 0.01 when compared to AUD.