Table 1.
Clinical characteristics of the cohorts.
| Characteristics | Discovery cohort | Validation cohort | |||||
|---|---|---|---|---|---|---|---|
| AIH (n=46) | HC (n=92) | P value* | AIH (n=22) | HC (n=44) | P value* | P value† | |
| Demographics | |||||||
| Age, years, median(min–max) IOR | 52(39-69) 9 | 52.5(25-72) 5 | 0.586 | 49.5(25-72) 11 | 50(28-77) 7 | 0.897 | 0.108 |
| Gender, Female,n(%) |
41(89.13%) | 80(86.96%) | 0.714 | 18(81.81%) | 34(77.27%) | 0.667 | 0.415 |
| BMI,kg/m2, median(min–max) IQR | 21.435 (18.37-23.91) 2.213 |
21.975 (18,37-24,57) 2.497 |
0.067 | 21.32 (18.471-23.81) 2.455 |
21.23 (18.52-23.44) 2.698 |
0.391 | 0.932 |
| Hepatic function, median (min-max) IQR | |||||||
| ALT, U/L | 145(47-553) 97 | 15(7-38) 6 | 0.000 | 135.5(56-415) 103 | 19(7-99) 13 | 0.000 | 0.338 |
| AST, U/L | 96.5(40-407) 66 | 19(11-33) 5 | 0.000 | 101(47-301) 53 | 21(14-36) 7 | 0.000 | 0.546 |
| AKP, U/L | 69(40-263) 22 | 70.5(32-157) 31 | 0.575 | 61(50-351) 26 | 63.5(32-157) 35 | 0.295 | 0.332 |
| GGT, U/L | 89(54-321) 40.5 | 18(6-64) 11.25 | 0.000 | 95(54-120) 38.5 | 14(7-80) 10.05 | 0.000 | 0.365 |
| TB, umol/L | 21(6-89) 14.5 | 12(4-30) 5.25 | 0.000 | 33.5(9-98) 17 | 12(6-29) 6.5 | 0.000 | 0.088 |
| ALB, g/L | 38.5(29-54) 11 | 48.25(39.6-55.2) 4.5 | 0.000 | 42.5(29-48) 9 | 48.05(40.6-53.3) 6.5 | 0.000 | 0.108 |
| Immunoglobulin, median (min–max) IQR | |||||||
| IgG, g/L | 21.39(9.82-44) 5.39 | 21.9(18.3-25.3) 3.62 | 0.605 | ||||
| IgM, g/L | 1.55(0.51-5.3) 1.32 | 1.6(0.8-3.2) 0.93 | 0.777 | ||||
| IgA, g/L | 2.15(0.6-8.63) 0.69 | 3.2(1.2-4.2) 0.85 | 0.159 | ||||
| Autoantibody, +/-, +% | |||||||
| ANA | 42/4,91.3 | 20/2,90.91 | 0.975 | ||||
| ASMA | 10/36,21.74 | 4/18,18.18 | 0.732 | ||||
| SLA/LP | 9/37,19.57 | 3/19,13.64 | 0.541 | ||||
*Comparisons between AIH and controls.
†Comparisons between AIH in exploration cohort and those in the validation cohort.
Use SPSS v. 20.0 (IBM Corp., Armonk, NY, USA) to analyze the data. Calculate the statistical significance of the differences between groups. Compare categorical variables by Fisher’s exact test. Compare continuous variables by the Wilcoxon rank-sum test. Correlation analysis was conducted by Spearman’s rank test.
BMI, body mass index; AIH, autoimmune hepatitis; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AKP, alkaline phosphatase; GGT, gamma-glutamyltransferase; TB, total bilirubin; ALB, albumin; IgG, Immunoglobulin G; IgM, Immunoglobulin M; IgA, Immunoglobulin A; ANA, antinuclear antibody; ASMA, anti-smooth muscle antibody; SLA/LP, soluble liver antigen/liver pancreas antigen; IQR, interquartile range.