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. Author manuscript; available in PMC: 2021 Jul 24.
Published in final edited form as: J Mol Biol. 2020 Jun 27;432(16):4722–4744. doi: 10.1016/j.jmb.2020.06.021

Fig. 5. MAS SSNMR comparison of ΔN15-Q44-HttEx1 and Q44-HttEx1 fibrils.

Fig. 5.

(a) Top: 1D cross polarization (CP) 13C spectrum of Q44-HttEx1 [36] and (middle) ΔN15-Q44-HttEx1, and (bottom) their overlaid comparison, normalized to the peak maxima for Q44-HttEx1. Spectral differences are consistent with the absence in the latter sample of the partly immobilized httNT seen in HttEx1 fibrils. (b) From top to bottom: 13C INEPT of Q44-HttEx1, ΔN15-Q44-HttEx1, and overlaid. The CP spectra feature signals from rigid and partly immobilized parts of the structure, while the INEPT data show only highly flexible residues. The spectra of Q44-HttEx1 are reprinted with permission from Lin et al. (2017) Nature Communications [36].