Fig. 4.

Pre-treatment with tryptase or chymase altered Poly (I:C) induced IL-8 release in HBECs. HBECs were pre-treated with tryptase or chymase for e hours and then stimulated with Poly (I:C) for 3 and 24 h. IL-8 mRNA expression 3 h (a) and 24 h (b). IL-8 protein release 3 h (c) and 24 (d). Data are presented as mean ± SEM, n = 4 from 4 independent experiments. *P < 0.05, **P < 0.01, **P < 0.001, ****P < 0.0001 compared to respective control and ^#P < 0.05, ^##P < 0.05 compared to Poly (I:C) alone