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Pre-treatment with tryptase decreased Poly (I:C) induced IFNs and PRR gene expression in asthmatic primary HBECs. Primary HBECs were pre-treated with tryptase followed by stimulation with Poly (I:C). Gene expression was measured in cell lysate. Pre-treatment with tryptase impaired gene expression of poly (I:C) induced IFN-β (a), TLR-3 (b), MDA-5 (c) and RIG-I (d). Data are presented as mean ± SEM, n = 3 asthmatic donors
