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. 2021 Apr 5;30(11):1006–1019. doi: 10.1093/hmg/ddab100

Figure 6 .

Figure 6

Pharmacological activation of SERCA increased muscular strength in mdx mice and C57BL/6J mice. (A and B) Grip strength measurement (A) and time to exhaustion in the treadmill test (B) in mdx mice treated with vehicle or CDN1163 for 7 weeks (n = 7 mice per group). (C) Voluntary wheel running test (n = 4 mice per group). The number of wheel revolutions was recorded over a week, and the total wheel count per week is shown. (D) Specific twitch and tetanic force of TA and GC muscles (n = 4 mice per group). (E and F) Grip strength measurement (E) and time to exhaustion in the treadmill test (F) in BL6 mice treated with vehicle or CDN1163 for 16 days (n = 3 mice per group). (G) Specific twitch and tetanic force of isolated TA and GC muscles of BL6 mice (n = 3 mice per group). We injected DMSO and Tween-80 at a final concentration of 10% v/v each into all experimental mice in vehicle group. Data are presented as the means ± SEMs. *P < 0.05, **P < 0.01, by Student’s t-test.