Table 7.

Advantages and disadvantages of commonly used biomaterials for cancer immunotherapy.

Biomaterials	Advantage	Disadvantage
Zinc	Easily functionalized, capability for multimodal imaging, optical and piezoelectric properties, antibacterial and antifungal nature.	Low stability, non-uniform size distribution, requirement of advanced equipment, risk of cytotoxicity and genotoxicity, skin and environment hazard
PLGA	High reproducibility and purity over natural polymer, no requirement of highly toxic solvents.	High size variability with change in concentration, low drug entrapment efficiency, high-cost, lack of surface functionalization
PLHMGA	Tailorable release rate, better compatibility with protein, not susceptible to acids during degradation	Difficult to prepare
Chitosan	High biocompatibility and biodegradability, wound healing and antimicrobial properties.	Low solubility in physiological pH, low porosity, stability & mechanical resistance.