Table 1.
Baseline characteristics, EORTC QLQ-C30 scores and EQ-5D-5L scores (ITT population)
| Characteristic | D-VMP (n = 350) | VMP (n = 356) |
|---|---|---|
| Age, years | ||
| Mean (SD) | 71.3 (6.66) | 71.5 (5.82) |
| < 65, n (%) | 36 (10.3) | 24 (6.7) |
| 65 to < 75, n (%) | 210 (60.0) | 225 (63.2) |
| ≥ 75, n (%) | 104 (29.7) | 107 (30.1) |
| Male, n (%) | 160 (45.7) | 167 (46.9) |
| Race, n (%) | ||
| White | 297 (84.9) | 304 (85.4) |
| Black or African American | 3 (0.9) | 3 (0.8) |
| Asian | 47 (13.4) | 45 (12.6) |
| Other, Unknown or Not reported | 3 (0.9) | 4 (1.1) |
| ECOG performance status, n (%) | ||
| 0 | 78 (22.3) | 99 (27.8) |
| 1 | 182 (52.0) | 173 (48.6) |
| 2 | 90 (25.7) | 84 (23.6) |
| EORTC QLQ-C30 GHS score, mean (SD) | ||
| GHS | 50.74 (20.996) | 52.40 (22.691) |
| EORTC QLQ-C30 functional scores, mean (SD) | ||
| Physical functioning | 59.96 (26.756) | 63.65 (25.701) |
| Role functioning | 57.54 (34.250) | 61.06 (33.192) |
| Emotional functioning | 69.70 (24.735) | 71.10 (22.304) |
| Cognitive functioning | 80.49 (21.998) | 83.38 (19.948) |
| Social functioning | 70.41 (28.468) | 70.64 (28.651) |
| EORTC QLQ-C30 symptom scores, mean (SD) | ||
| Pain | 46.10 (33.130) | 43.12 (31.429) |
| Fatigue | 42.48 (25.661) | 41.05 (25.798) |
| Nausea/vomiting | 5.38 (12.425) | 5.45 (13.566) |
| Dyspnea | 18.35 (24.930) | 19.37 (24.742) |
| Insomnia | 29.54 (30.044) | 27.93 (31.135) |
| Appetite loss | 22.26 (28.116) | 21.81 (26.623) |
| Constipation | 23.00 (31.517) | 18.86 (27.404) |
| Diarrhea | 5.91 (17.015) | 5.40 (15.270) |
| Financial difficulties | 18.88 (26.534) | 17.33 (24.743) |
| EQ-5D-5L scores, mean (SD) | (n = 316) | (n = 325) |
| VAS | 57.72 (20.254) | 60.32 (20.556) |
SD standard deviation
Higher EORTC QLQ-C30 scores represent greater GHS, better functioning and worse symptoms. Higher EQ-5D-5L VAS score represents better health