Table 3.
HRs for comparison of time to worsening of EORTC QLQ-C30 scale scores by depth of response and MRD status for pooled treatment arms
| EORTC QLQ-C30 scales | Clinical response | MRD− vs MRD+ | ||||
|---|---|---|---|---|---|---|
| (s)CR vs VGPR/PR | SD vs VGPR/PR | |||||
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| GHS | 0.72 (0.54–0.96) | 0.025 | 1.75 (1.16–2.66) | 0.008 | 0.70 (0.50–0.99) | 0.042 |
| Physical functioning | 0.88 (0.66–1.17) | 0.365 | 1.60 (0.05–2.45) | 0.031 | 0.79 (0.57–1.10) | 0.168 |
| Role functioning | 0.93 (0.72–1.20) | 0.578 | 1.55 (1.05–2.27) | 0.027 | 0.84 (0.62–1.12) | 0.235 |
| Emotional functioning | 0.79 (0.57–1.07) | 0.120 | 1.87 (1.21–2.88) | 0.005 | 0.93 (0.66–1.31) | 0.680 |
| Cognitive functioning | 0.81 (0.64–1.02) | 0.075 | 1.28 (0.88–1.85) | 0.200 | 1.02 (0.78–1.32) | 0.910 |
| Social functioning | 0.87 (0.67–1.13) | 0.290 | 1.50 (1.01–2.23) | 0.044 | 0.89 (0.66–1.21) | 0.453 |
| Pain | 0.72 (0.56–0.94) | 0.017 | 1.22 (0.81–1.86) | 0.340 | 0.60 (0.43–0.83) | 0.002 |
| Fatigue | 1.01 (0.88–1.29) | 0.950 | 1.44 (0.99–2.10) | 0.060 | 0.98 (0.74–1.29) | 0.023 |
| Nausea/vomiting | 1.05 (0.80–1.39) | 0.733 | 1.38 (0.88–2.16) | 0.158 | 0.92 (0.67–1.27) | 0.610 |
| Dyspnea | 0.64 (0.48–0.84) | 0.002 | 1.42 (0.94–2.15) | 0.096 | 0.71 (0.51–0.98) | 0.037 |
| Insomnia | 0.80 (0.62–1.04) | 0.099 | 1.26 (0.84–1.90) | 0.265 | 0.83 (0.61–1.12) | 0.215 |
| Appetite loss | 1.05 (0.80–1.39) | 0.716 | 1.67 (1.10–2.55) | 0.017 | 0.96 (0.71–1.31) | 0.596 |
| Constipation | 0.80 (0.61–1.06) | 1.127 | 1.30 (0.84–2.02) | 0.233 | 0.92 (0.67–1.26) | 0.596 |
| Diarrhea | 1.03 (0.77–1.38) | 0.832 | 1.39 (0.87–2.24) | 0.172 | 0.89 (0.63–1.24) | 0.475 |
PR partial response; (s)CR (stringent) complete response; SD stable disease; VGPR very good partial response
Worsening of EORTC QLQ-C30 GHS defined as a ≥ 10-point decrease and worsening of EORTC QLQ-C30 pain and fatigue defined as a ≥ 10-point increase