Table 8.

Interacting amino acids for Drugs having G-Score above Hydroxyquinoline for Papain Protease of SARS-COV-2 (PDB ID: 6W9C).

Compound	Mode of Action	Hydrophobic	Polar	п-п Stacking	H-Bond	Charged
	Antimalarial, Anti-inflammatory	Chain A: Gly160, Leu162 Chain B: Leu162, Val159, Cys270, Gly160 Chain C: Leu162, Val159 Gly160, Trp106, Cys270	Chain A: Asn109, Gln269 Chain B: Asn109, Gln269 Chain C: Asn109, His89, Gln269	Chain B: Glu161 Chain C: Asn109, Asp108		Chain A: Glu161 Chain B: Glu161, Asp108 Chain C: Asp108
	Tyrosine Kinase inhibitor; Epidermal Growth Factor Receptor (EGFR) inhibitor	Chain A: Val159, Gly160, Leu162 Chain B: Val159, Gly160, Trp106, Cys270 Chain C: Val159, Leu162, Gly160, Cys270	Chain A: Asn109, Gln269, Thr158 Chain B: Asn109, Gln269, His89 Chain C: Thr158, Gln 269, Asn109		Chain C: Asn109	Chain A: Glu161, Chain B: Asp108, Chain C: Glu161
	Anti-HIV Protease inhibitor	Chain A: Leu162, Val159, Gly160 Chain B: Leu162, Val159, Cys270 Chain C: Leu162, Val159, Cys270, Gly160	Chain A: Thr158, Asn109, Gln269 Chain B: Thr158, Asn109, Gln269, His89, Ser85 Chain C: Thr158, Asn109, Gln269,	Chain B: Leu162, Val159, Gly160 Chain C: Asp108, Asn109		Chain A: Glu161 Chain B: 161 Chain C: Glu161, Asp108
	Anti-HIV Protease inhibitor	Chain A: Val159, Gly160, Leu162 Chain B: Leu162, Cys270, Gly160 Chain C: Cys270, Leu162, Val159	Chain A: Asn109, Thr158, Gln269 Chain B: Asn109, Gln269 Chain C: His89, Gln269			Chain A: Asp108, Glu161 Chain B: Glu161 Chain C: Glu161, Asp108
	ꞵ2 adrenoceptors agonist, muscarinic receptor antagonist	Chain A: Val159, Ala86 Chain B: Leu162, Tyr171, Gly160 Chain C: Trp93, Ala107, Val159	Chain A: Thr58, Ser85, His89 Chain B: Asn156, His89	Chain C: Asp108, Chain B: Glu161		Chain A: Glu161, Arg82, Lys157 Chain B: Glu167, Glu161 Chain C: Lys92, Asp108
	Antineoplastic Inhibits RNA Polymerase activity	Chain A: Val159, Leu162, Ala86, Gly160 Chain B: Val159, Cys270 Chain C: Leu162, Cys270, Gly160	Chain A: Thr158, Ser85, His89, Gln269 Chain B: Gln269, His89, Asn109 Chain C: Asn109, Gln269, Thr158	Chain A: Val159		Chain A: Arg82, Glu161 Chain B: Asp108 Chain C: Glu161
	Antimalarial Drug Anti-arthritis	Chain A: Leu162, Gly160 Chain B: Leu162, Val159, Cys270, Gly160	Chain A: Asn109, Gln269, Thr158, Chain B: Thr158, Gln269, Asn109 Chain C: Asn109, Gln269	Chain A: Gly160 Chain B: Val159,	Chain A: Gly160 Chain B: Val159	Chain A: Glu161 Chain B: Glu161
	Topoisomerase Inhibitor	Chain A: Leu162, Val159 Chain B: Val159, Gly160, Leu162, Cys270 Chain C: Val159, Leu162, Gly160, Cys270	Chain B: Thr158, Gln269, Asn109 Chain A: Gln269, Thr158, Asn109 Chain C: Asn109, Gln269	Chain B: Gly160		Chain B: Glu161, Asp108 Chain A: Arg108 Glu161 Chain C: Glu161, Asp108
	Anti-HIV Inhibitor	Chain A: Leu162 Chain B: Leu162, Gly160, Cys270, Val159 Chain C: Leu162, Gly160, Val159	Chain A: Thr158, Asn109, Gln269 Chain B: Thr158, Gln269, Asn109 Chain C: Asn109, Gln269	Chain B: Leu162, Val159		Chain B: Glu161 Chain A: Glu161 Chain C: Asp108
	Antimalarial Drug	Chain A: Leu162, Gly160 Chain B: Leu162, Gly160, Cys270, Val159 Chain C: Leu162, Gly160	Chain A: Thr158, Gln269 Chain B: Thr158, Gln269, Asn109, His89 Chain C: Asn109, Gln269	Chain B: Asn109		Chain A: Glu161 Chain B: Asp108 Chain C: Glu161
	Tyrosine Kinase inhibitor; Epidermal Growth Factor Receptor (EGFR) inhibitor	Chain A: Leu162, Gly160 Chain B: Leu162, Gly160, Cys270, Chain C: Leu162, Gly160, Ala86, Val159, Cys270	Chain A: Asn109, Gln269 Chain B: Asn109, Gln269 Chain C: Asn109, Gln269, His89, Thr158, Ser85	Chain C: Val159		Chain A: Glu161 Chain B: Glu161 Chain C: Glu161, Asp108
	Antiviral Drug	Chain A: Leu162, Gly160, Val159 Chain B: Leu162, Gly160, Cys270, Val159 Chain C: Leu162, Gly160, Val159, Cys270	Chain A: Asn109, Thr158, Gln269 Chain B: Gln269, Asn109, His89, Thr158 Chain C: Gln269, Asn109, Thr158	Chain C: Asn109 Chain B: Asn109, Gly160		Chain A: Glu161 Chain B: Asp108, Glu161 Chain C: Glu161, Asp108