Table 12.

Interacting amino acids for compounds having G-Score above Hydroxyquinoline and Galidesivir for RNA dependent RNA Polymerase of SARS-COV-2 (PDB ID 7BTF).

Compound	Mode of Action	Hydrophobic	Polar	H-Bond	п-п stacking	Charged
	Potent Irreversible EFGR receptor	Tyr455, Ala554, Val557, Tyr619, Pro620, Cys622	Thr556, Ser682, Ser759	Asp760, Asp760, Arg553, Arg553, Asp623, Asp623, Asp623	Lys621, Arg553, Arg553	Lys621, Arg553, Arg624, Arg555, Arg545, Asp452, Asp623, Asp760, Asp761
	DNA Topoisomerase inhibitor	Tyr455, Tyr619, Pro620, Cys622, Ala550	Ser549	Asp760, Asp760, Asp623, Lys621, Tyr619	Lys621, Arg553, Arg553	Lys798, Arg621, Arg624, Arg555, Arg553, Lys551, Asp623, Asp618, Asp761, Asp760
	Antimalarial, Anti-inflammatory	Tyr455, Cys622, Pro620, Tyr619, Trp617, Ala762		Asp761, Trp617, Asp760, Lys621, Asp761	Arg553, Lys621	Lys551, Arg553, Arg555, Arg624, Lys621, Lys798, Asp623, Asp618, Asp761, Asp760
	Antimalarial	Tyr455, Cys622, Pro620, Tyr619, Trp617, Ala762	Ser759	Asp760, Asp760, Asp761	Lys621, Arg553, Arg553, Asp452	Lys551, Arg553, Asp452, Arg624, Asp623, Lys621, Asp618, Asp760, Asp761, Lys798
	Antibiotic	Tyr455, Ala554, Cys622, Pro620, Tyr619, Trp617, Ala762, Trp800, Phe812, Cys814	Thr556, Ser682, Ser814	Asp452, Asp623, Asp761, Trp617	Arg553, Arg553	Arg553, Arg555, Arg624, Lys621, Lys798, Asp452, Asp623, Asp618, Asp761, Asp760, Glu811
	Anti-HIV inhibitor	Tyr619, Pro620, Cys622, Tyr455,	Asn691, Thr680, Ser682, Thr556	Arg553, Asn691, Arg555	Lys621, Arg553	Asp618, Asp760, Asp623, Lys621, Arg624, Arg553, Arg555,
	Antiviral activity against positive and negative sense RNA viruses for example: Ebola, Marburg, Yellow fever, Zika virus	Tyr619, Pro620, Cys622, Tyr455	Thr556	Asp623, Asp618, Tyr619		Asp618, Asp760, Asp623, Asp452, Lys798, Lys621, Arg624, Arg553, Lys551
	Antimalarial Drug Anti-arthritis	Cys622, Pro620, Tyr619, Tro617, Trp800, Ala762, Phe812, Cys813	Ser814	Asp760, Asp761, Asp761, Asp761, Asp623	Lys621	Asp623, Lys621, Asp618, Asp760, Asp761, Glu811, Lys798
	Toll-like receptor 7 Agonist	Tyr619, Pro620, Cys622, Tyr455		Asp623, Arg553, Arg555	Lys621, Arg553	Lys621, Asp623, Asp618, Lys798, Arg624, Asp760, Asp452
	β2 adrenoceptors agonist, muscarinic receptor antagonist	Cys622, Pro620, Tyr619, Trp617, Tyr455, Ala554	Ser759, Asn691, Thr556, Ser814	Lys621, Asp618, Asp760, Ala554	Lys621, Tyr455, Arg553	Lys621, Arg624, Asp623, Asp618, Lys551, Arg553, Arg555, Asp760, Asp761
	Anti-HIV Protease Inhibitor	Tyr619, Trp617, Pro620, Cys622, Ala762, Ala688	Ser682, Thr687, Asn691, Thr556, Ser759	Asp760, Asp623, Arg553, Arg555, Thr556		Asp618, Glu811, Lys621, Arg624, Asp623, Lys545, Asp684, Arg555, Arg553, Asp760, Asp761
	Tyrosine Kinase inhibitor; Epidermal Growth Factor Receptor (EGFR) inhibitor	Chain A: Tyr455, Ala554, Ala448	Chain A: Asn552, Ser451, Asn447, Gln444 Chain C: Gln34	Chain A: Ala554, Asp445	Chain A: Arg553, Ala554	Chain A: Lys621, Arg624, Lys551, Arg553, Asp623, Asp445
	Tyrosine Kinase inhibitor; Epidermal Growth Factor Receptor (EGFR) inhibitor	Pro620, Cys622, Val166, Tyr455, Ala688	Ser759, Asn691, Thr680, Ser681, Ser682	Asp623, Lys621	Arg553	Lys798, Glu167, Asp760, Asp623, Arg624, Lys621, Arg553, Lys551
	Antiviral Drug	Tyr619, Val166, Pro620, Cys622, Met626, Tyr455	Ser759, Thr680, Asn691, Asn552	Lys798, Lys621, Cys622	Arg553, Lys621	Asp618, Lys798, Lys621, Arg624, Asp623, Lys551, Arg553, Asp760