Table 4.

Summary of Findings for PICO Question 4^a

Elemental diets compared to placebo for the management of EoE
Outcomes and follow-up	No. of participants (studies)56–61	Certainty of the evidence (GRADE)	Relative effect, RR (95% CI)	Anticipated absolute effects
				Risk with placebo	Risk difference with elemental diets
Not achieving histologic remission (eos <15/hpf) follow-up: mean 8 wk	431 (6 observational studies)b,c,d	⊕⊕⊕◯ MODERATEe	0.07 (0.05–0.12)	880 per 1000	807 fewer per 1000 (824 fewer to 763 fewer)

^aThe risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

^bFive subjects excluded for noncompliance to diet; 2 subjects excluded for not getting follow-up endoscopy (Kelly et al⁵⁶).

^cEight subjects excluded for noncompliance (Licarous et al⁵⁷).

^dHistologic remission defined as <10 eos/hpf; 11 who started diet dropped out (Peterson et al⁵⁹).

^eUpgraded for very large effect size.