. Author manuscript; available in PMC: 2021 Jun 2.

Published in final edited form as: Ann Allergy Asthma Immunol. 2020 May;124(5):424–440.e17. doi: 10.1016/j.anai.2020.03.021

Table 6.

Summary of Findings for PICO Question 5b^a

4-Food empiric elimination diet compared to placebo for EoE
Outcomes and follow-up	No. of participants (studies)^37,67,70	Certainty of the evidence (GRADE)	Relative effect, RR (95% CI)	Anticipated absolute effects
Outcomes and follow-up	No. of participants (studies)^37,67,70	Certainty of the evidence (GRADE)	Relative effect, RR (95% CI)	Risk with placebo	Risk difference with 4-food empiric elimination diet
Not achieving histologic remission (no remission) assessed with: <15 eos/hpf follow-up: 6 wk	426 (3 observational studies)^b	⊕⊕◯◯ LOW	0.49 (0.42–0.57)	880 per 1000^c	449 fewer per 1000 (510 fewer to 378 fewer)

The risk in the intervention group (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

Pediatric study (Molina-Infante et al⁶⁷).

Placebo group responses from topical steroid trials.