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A proposed novel pathway for HGF-induced EMT of HCC cells. FUT8 is over-expressed in HGF or TGF-β1-treated HCC cells, which results in the up-regulation of core-fucosylation on FOLR1. The increased core-fucosylation on FOLR1 especially at the glycosite Asn-201 enhances the folate uptake capacity of the cell, providing sufficient dose of folates for promoting the EMT of HCC cells.
