Figure 1.

Diagram of the biofunction of the peptide-derived MDMX degrader, MG, and its nanoengineering strategy. A peptide-derived PROTAC was design that is capable of binding in crevices at the surfaces of MDMX and Von Hippel Lindau factor termed VHL (a component of the Cul2-Rbx1-EloB/C-VHL E3 ligase). A nanoengineered gold(I)-peptide cluster (Nano-MP) was synthesized by an aurophilicity-driven self-assembly among Au-peptide precursors [Au(I)-S-MP]_n. Of note, this gold-derived nanocluster possesses high loading efficiency as the cargo MP themselves were utilized as building blocks.