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. 2021 May 3;11(14):6833–6846. doi: 10.7150/thno.59020

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Nano-MP@PSI can GSH-triggered release cargo and be excreted from the body. A, diagrammatic drawing of the GSH-triggered release of cargo (MG) and size change of Nano-MP. B, TEM images of Nano-MP@PSI at 0h and 4h after 5 mM GSH incubation at pH 7.4. C, peptide release from Nano-MP@PSI under 5mM GSH or 5μM solutions at pH 7.4. Peptide release was quantified by HPLC, and the date was showed by Mean±SD. D, tissue kinetics of Nano-MP in BALB/c mice after intravitreal injection. Serial sacrifices were carried out at 1h, 2h, 4h, 8h, 12h and 14 days after dosing. Several organs/tissues, including eye, heart, liver, spleen, lung, kidney and brain were isolated to determine gold concentrations by ICP-MS. The data were shown as mean ± SD.