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. 2021 May 3;11(14):6833–6846. doi: 10.7150/thno.59020

Figure 6.

Figure 6

Nano-MP@PSI potently suppressed retinoblastoma in an orthotopic xenograft mouse model. A, Schematic diagram of therapeutic treatments. Athymic nude mice (BALB/c) bearing WERI-Rb1xenograft tumors were established and randomly divided into three groups (n = 5/group). Mice were then treated by intraperitoneal injection at day 1, 5, 9 of PBS, Nano-MP@PSI (1.5 mg/kg) or Nano-DPMI@PSI (1.5 mg/kg). B, Photographic images from BALB/c mice bearing WERI-Rb1 xenograft tumors with the indicated treatments. C, Representative tumor sections after the 11-day treatment staining by H&E (X 200). D, Representative TUNEL and IHC images for Ki67, MDMX, p53, and p21 in tumor sections (scale bar: 60 µm).