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Prognostic value of serial ctDNA in patients with CRLM. Kaplan-Meier survival analysis shows the probability of recurrence-free survival (RFS) stratified by ctDNA status of baseline (A), pre-operation (B), post-operation (C), and post-ACT (D). (E) Dichotomized association between disease recurrence and ctDNA status in the post-operative and post-ACT setting. (F) Time-dependent ROC curves of survival prediction between the CRS and VAF of ctDNA at four-time points.
