Figure 1.

The first-line chemotherapy led to genomic changes in lung cancer tissues. (A) a linear relationship between the number of mutations before and after chemotherapy in paired cancer tissues. (B) scatter plot of the number of mutations before and after chemotherapy; data are presented in log value for pre-therapeutic, post-therapeutic, and common mutations; (C) significant non-synonymous mutations before chemotherapy; (D) significant non-synonymous mutations after chemotherapy; (E) differential mutated genes in paired tissues; (F) lollipop chart for the mutated amino acids of TP53 before and after chemotherapy (the upper one is post-therapeutic, the lower one is pre-therapeutic).