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. 2021 May 13;11(14):7092–7109. doi: 10.7150/thno.58039

Figure 2.

Figure 2

Changes of mutational signature and other mutation characteristics during the chemotherapy. (A) the mutational signature and the clusters of patients before chemotherapy; (B) the mutational signature and clusters of patients after chemotherapy; (C) OS of different clusters before chemotherapy (because only 1 patient was in cluster 3, the cluster 3 was not included in survival analysis); (D) the percentage of unique SNV and INDEL mutations before and after therapy and common mutations of each patients; (E) box and whisker plot for the percentage of unique SNV and INDEL mutations before and after therapy and common mutations for all patients; (F) TMB values for patients with PR/SD and PD (bars represent mean with 95%CI); (G) TMB values for patients with PR and SD/PD (bars represent mean with 95%CI).