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. 2021 May 3;11(14):6800–6817. doi: 10.7150/thno.56989

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CAR-T cellular visualization based on eDHFR reporter imaging. After receiving eDHFR-expressing anti-GD2 CAR-T cells, mice bearing both GD2^- HCT116 (left shoulder) and GD2⁺ 143b tumor (right shoulder) were imaged with BLI and ¹⁸F-TMP PET for CAR-T cellular visualization. The images showed elevated BLI and PET signal in the spleen on day 7 post T cells infusion (p.t), which decreased on day 13 p.t (A, red arrows). Neither GD2^- nor GD2⁺ tumor displayed BLI or PET signal on day 7 p.t, whereas increased BLI and PET signal was detected only in GD2⁺ tumor (B, red arrows) on day 13 p.t. Adapted with permission from ⁸⁴, copyright 2019 The American Society of Gene and Cell Therapy.