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. 2021 May 8;11(14):6936–6949. doi: 10.7150/thno.58173

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The Ncom Gel vaccine dramatically inhibits melanoma growth in C57BL/6 mice. (A) Treatment scheme for C57BL/6 mice with B16F10-OVA tumors. (B) Average tumor growth curves of B16F10-OVA tumor-bearing mice were recorded after treatment with PBS, OVA/CpG, OVA/OX-M, OVA/NOCC-CpG, OVA/Ncom Gel, OVA/alum or NcomGel (n=6; data are represented as the means ± SEM and analyzed with two-way ANOVA with Bonferroni correction tests. * P < 0.05, **P < 0.01, *** P< 0.001 and **** P< 0.0001.) (C) Survival curves of mice after the mentioned treatments. (D) Body weight curves were recorded during the treatment. (E) Individual mouse tumor growth curves in different treatment groups.