Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 19;13:632448. doi: 10.3389/fnagi.2021.632448

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Chen, Yang, Yang, Liu, Li, Wu, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Differential expression of circRNAs in IA tissues. (A) The constituent of upregulated circRNAs. (B) The constituent of downregulated circRNAs. (C) The scatterplot is used for assessing the circRNA expression variation between the two compared samples or two compared groups of samples. The values of X and Y axes in the scatterplot are the normalized signal values of the samples (log₂ scaled) or the averaged normalized signal values of groups of samples (log₂ scaled). The green lines are Fold Change Lines. The circRNAs above the top green line and below the bottom green line indicate more than 1.5-fold change of circRNAs between the two compared samples. (D) Volcano Plots are used for visualizing differential expression between two different conditions. The vertical lines correspond to 1.5-fold up and down, respectively, and the horizontal line represents a p-value of 0.05. So the red point in the plot represents the differentially expressed circRNAs with statistical significance. Group A represented STA samples; group B represented IA samples. (E) The hierarchical clustering of differentially expressed circRNAs. “Red” indicates high relative expression, and “green” indicates low relative expression. Group A represented STA samples; group B represented IA samples. (F) Validation of the differential expression of five upregulated circRNAs. (G) Validation of the differential expression of hsa_circRNA_101833 in another five coupled groups. STA, superficial temporal arteries; IA, IA.