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. 2021 May 19;12:668760. doi: 10.3389/fimmu.2021.668760

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Copyright © 2021 Cheng, Ding, Liu, Li, Tang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of miR-30e-5p on the differentiation of naive CD4+ T cells from patients with SLE. (A) Venn diagram and heatmap analysis of miRNA expression profiles in Treg and Th17 differentiation from naive CD4+ T cells before and after RvD1 treatment. (B) The expression of miR-30e-5p, miR-32-5p, miR-26a-2-3p and let-7a-3p were verified by qPCR in independent SLE patients (n=10). (C, D) Representative flow cytometric plots indicated the percentage of Treg and Th17 cells polarized from naive CD4+ T cells transfected with miR-30e-5p mimic or inhibitor. (E) The level of TGF-β1, IL-10, and IL-17 in supernatant were detected by ELISA. All data are mean ± SEM. n=5 per group. ***p < 0.001.