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. 2021 Jun 2;11:341. doi: 10.1038/s41398-021-01452-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Graphical illustration of main top-down, central nervous system (CNS)–Brain/CSF to periphery, and bottom-up (periphery to CNS) communication pathways through the receptors and summary of peripheral and central pathology through interleukins—IL-6 and Il-1β and neurotrophins, BDNF, and GDNF. Factors that are associated with the analyses are suicidality, age, gender, psychiatric medications, RIN, pH, and PMI.