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Purified dentilisin and T. denticola upregulate RASA4 gene expression in PDL cells. Quantitative RT-PCR analysis of RASA4 relative fold change in PDL cells challenged with V. parvula, wild type T. denticola, T. denticola dentilisin mutant CF522, T. denticola MHE or treated with purified dentilisin for 24 h. Data represent mean ± SD from three independent experiments. Data were compared using One-way ANOVA Tukey’s Multiple comparisons test. * = p<0.05.
