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. 2021 Jun 1;5(6):e582. doi: 10.1097/HS9.0000000000000582

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Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 3. — Cell-of-origin of GC-derived lymphomas. Distinct types of GC-derived lymphomas originate from cells that are blocked at different stages of maturation. Burkitt lymphomas resemble DZ B cells, follicular lymphomas and GCB-DLBCL originate from LZ B cells, and ABC-DLBCL display characteristics of late GC B cells that are committed to post-GC differentiation. A subset of DLBCL carrying a DHIT signature related to aberrant expression and/or activity of MYC proto-oncogene, bHLH transcription factor and BCL2 apoptosis regulator (and/or BCL6 transcription repressor) appear to originate from DZ GC B cells. ABC = activated B-cell like; CSR = class switch recombination; DHIT = double-hit; DLBCL = diffuse large B-cell lymphoma; DZ = dark zone; GC = germinal center; GCB = GC B-cell like; LZ = light zone; SHM = somatic hypermutation.