Table 1.
Relationship between methylation status of PRSS3 gene and clinicopathological features in human HCC
| Clinicopathologic factor | n (%) | PRSS3 methylation status |
p value* | |
|---|---|---|---|---|
| Methylation n (%) | Unmethylation n (%) | |||
| Age (years) | ||||
| < 50 | 22 (33.3) | 19 (35.8) | 3 (23.1) | 0.815 |
| ≥ 50 | 44 (66.7) | 34 (64.2) | 10 (79.2) | |
| Sex | ||||
| Male | 52 (78.8) | 42 (79.2) | 10 (76.9) | 0.845 |
| Female | 14 (21.2) | 11 (20.8) | 3 (23.1) | |
| HBsAg | ||||
| Negative | 17 (25.8) | 13 (24.5) | 4 (30.8) | 0.971 |
| Positive | 49 (74.2) | 40 (75.5) | 9 (69.2) | |
| Liver cirrhosis | ||||
| Negative | 25 (37.3) | 21 (38.9) | 4 (30.8) | 0.823 |
| Positive | 42 (62.7) | 33 (61.1) | 9 (69.2) | |
| Size (diameter) | ||||
| < 5 cm | 20 (30.3) | 15 (28.3) | 5 (38.5) | 0.475 |
| ≥ 5 cm | 46 (69.7) | 38 (71.7) | 8 (61.5) | |
| Differentiation | ||||
| Well | 6 (9.1) | 3 (5.7) | 3 (23.1) | 0.05 |
| Moderate and poor | 60 (90.9) | 50 (94.3) | 10 (76.9) | |
| TNM | ||||
| I/II | 34 (51.5) | 26 (49.1) | 8 (61.5) | 0.42 |
| III/IV | 32 (48.5) | 27 (50.9) | 5 (38.5) | |
| Metastasis | ||||
| Negative | 43 (65.2) | 33 (62.3) | 10 (76.9) | 0.993 |
| Positive | 23 (34.8) | 20 (37.7) | 3 (23.1) | |