Figure 1.

Detection of antiviral antibodies by VirScan. A, Heatmap of viral scores for detected viruses with the highest median viral scores. Cases and controls are in order (left to right) of increasing age. B, Frequency of samples testing “positive” for viral pathogens, defined by a viral score > 3 and antibody against an immunodominant epitope. Viruses present in at least 5% of Kawasaki disease (KD) samples are shown, and there were no significant differences between cohorts (Fisher exact test, all P values > .05). C, Heatmap depicting enrichment for antibodies against approximately 10 201 individual viral peptides detected in KD samples and controls. No individual peptide was enriched in KD samples vs controls (Fisher exact test, all samples with a Bonferroni-corrected P > .05).