| miRNA-122 |
Interleukin 1 receptor type 1 |
An important mediator involved in many cytokine-induced immune and inflammatory responses. |
| REL proto-oncogene, NF-kB subunit |
This gene belong to a family that Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. |
| PRKAB1 |
A regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. |
| miRNA-126-3p |
Insulin receptor substrate 1 |
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. |
| SPRED1 |
Act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. |
| TRAF6 |
This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to pro-inflammatory cytokines. |
| IL-6 |
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. |
| miRNA-146a |
TNF alpha induced protein 3 |
The protein encoded by this gene is a zinc finger protein and ubiquitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses |
| TNF receptor associated factor 3 |
This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappa B activation and cell death initiated by LTbeta ligation |
| IL-6 |
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. |
