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| Drug names | Limitations |
| Dolutegravir | Increases serum creatinine levels by 0.1-0.2 mg/dL. Can also cause drug-related insomnia [39]. |
| Bictegravir | Increases serum creatinine levels by 0.1-0.2 mg/dL [39]. |
| Raltegravir | Can cause rhabdomyolysis and myopathy, and is dosed twice daily. Can also cause drug-related insomnia [39]. |
