Table 3.
Diagnostic Accuracy of Colors and Dermoscopic Structures for Tumor Thickness ≥0.8 mm
| Feature | Sens. | Spec. | PPV | NPV | OR (95% CI) |
|---|---|---|---|---|---|
|
| |||||
| Color | |||||
| Red-pink | 51.6 | 81.3 | 63.6 | 72.6 | 4.641 (2.611–8.242) |
|
| |||||
| Blue-gray | 46.7 | 81.1 | 49.0 | 79.5 | 3.743 (2.044–6.853) |
|
| |||||
| White | 43.2 | 80.7 | 58.6 | 69.1 | 3.168 (1.785–5.626) |
|
| |||||
| Black | 57.9 | 46.0 | 40.4 | 63.3 | 1.123 (0.632–1.965) |
|
| |||||
| Dark brown | 83.2 | 6.0 | 35.9 | 36.0 | 0.315 (0.133–0.740) |
|
| |||||
| Light brown | 82.1 | 4.7 | 35.3 | 29.2 | 0.225 (0.081–0.562) |
| Three or more colors | 88.4 | 18.0 | 40.6 | 71.1 | 1.676 (0.789–3.563) |
|
| |||||
| Asymmetry of colors | 78.9 | 22.7 | 39.3 | 63.0 | 1.099 (0.589–2.051) |
|
| |||||
| Asymmetry of structures | 78.9 | 16.0 | 37.3 | 54.5 | 0.714 (0.370–1.380) |
|
| |||||
| Ulceration | 36.8 | 96.7 | 87.5 | 70.7 | 16.917 (6.326–45.265) |
|
| |||||
| Pseudolacunae | 24.2 | 98.0 | 88.5 | 67.1 | 15.653 (4.549–53.854) |
|
| |||||
| Blue-white veil | 57.9 | 86.0 | 72.4 | 76.3 | 8.446 (4.568–15.67) |
|
| |||||
| Rainbow pattern | 26.3 | 95.3 | 78.1 | 67.1 | 7.296 (3.018–17.687) |
|
| |||||
| Milky red areas | 35.8 | 89.3 | 68.0 | 68.7 | 4.668 (2.395–9.096) |
|
| |||||
| Blue-black pigmentation | 18.9 | 94.7 | 69.2 | 64.8 | 4.149 (1.724–9.983) |
|
| |||||
| Irregular vessels | 43.2 | 83.3 | 62.1 | 69.8 | 3.796 (2.102–6.855) |
|
| |||||
| Shiny white streaks | 54.7 | 70.7 | 54.2 | 71.1 | 2.913 (1.702–4.973) |
|
| |||||
| Structureless brown areas | 15.8 | 88.0 | 45.5 | 62.3 | 1.375 (0.656–2.880) |
|
| |||||
| Negative pigment network | 7.4 | 92.7 | 38.9 | 61.2 | 1.005 (0.376–2.690) |
|
| |||||
| Streaks | 18.9 | 80.0 | 37.5 | 60.9 | 0.935 (0.488–1.792) |
|
| |||||
| Irregular blotches | 42.1 | 49.3 | 34.5 | 57.4 | 0.708 (0.422–1.189) |
|
| |||||
| Irregular globules | 38.9 | 51.3 | 33.6 | 57.0 | 0.673 (0.399–1.134) |
|
| |||||
| Prominent skin markings | 5.3 | 91.3 | 27.8 | 60.4 | 0.585 (0.202–1.699) |
|
| |||||
| Atypical pigmented network | 34.7 | 48.7 | 30.0 | 54.1 | 0.505 (0.295–0.856) |
|
| |||||
| Regression | 25.3 | 54.7 | 26.1 | 53.6 | 0.408 (0.238–0.717) |
|
| |||||
| Hypopigmented areas | 6.3 | 84.7 | 20.7 | 58.8 | 0.372 (0.149–0.950) |
Sens. = sensitivity; Spec. = specificity; PPV = positive predictive value; NPV = negative predictive value; OR = odds ratio; CI = confidence interval.