Table 1. Selected Small Molecule Tools Targeting Wnt Pathway Components.
| compound identifier | molecular target | effect on canonical Wnt signaling | structural information in public domain | furthest progress to date | refs |
|---|---|---|---|---|---|
| ICG-001, 5 | CBP | inhibit | no | preclinical | (45) |
| IWP-2, 9 | Porcupine | inhibit | no | preclinical | (51) |
| endo-IWR-1, 11 | TNKS1/2 | inhibit | yes | preclinical | (51) |
| XAV939, 12 | TNKS1/2 | inhibit | yes | preclinical | (57,59) |
| G007-LK | TNKS1/2 | inhibit | yes | preclinical | (60,63) |
| NVP-TNKS656 | TNKS1/2 | inhibit | no | preclinical | (61) |
| MSC2504877 | TNKS1/2 | inhibit | no | preclinical | (62) |
| BML-268, 13 | DVL3 | inhibit | yes | early discovery | (65) |
| NPL-4011, 14 | DVL3 | inhibit | yes | early discovery | (66) |
| NSC654259, 15 | FZD8 | inhibit | yes | early discovery | (67) |
| carbamazepine, 16 | FZD8 | inhibit | yes | preclinicala | (68) |
| SRI37892, 17 | FZD7 | inhibit | yes | early discovery | (70) |
| gallocyanine, 21 | LRP6 | enhance | yes | early discovery | (77) |
| WAY-362692, 22 | sFRP-1 | enhance | no | preclinical | (82−84) |
| WAY-262611, 23 | DKK1 | enhance | no | preclinical | (85) |
| LP-922056, 26 | Notum | enhance | yes | preclinical | (95) |
| ABC99, 27 | Notum | enhance | no | preclinical | (118) |
| ARUK3001185, 28 | Notum | enhance | no | preclinical | (126) |
a
Carbamazepine is an approved anticonvulsant drug used clinically in the treatment of epilepsy and neuropathic pain.