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. 2021 May 20;17(5):e1009573. doi: 10.1371/journal.pgen.1009573

Fig 7. Crosstalk between LET-607 and DAF-16 depends on calcium signaling and calcium-sensitive kinase.

Fig 7

(A) Effects of itr-1 RNAi on let-607 knockdown-induced MTL-1::GFP expression. Left panel, representative images. Right panel: quantification data. Scale bar = 100 μm. (B-C) Effects of itr-1 mutation on let-607 RNAi-induced TBHP resistance (B) and longevity (C) in C. elegans. (D) Effects of sca -1 RNAi on the expression of MTL-1::GFP which is suppressed by sms-5 RNAi. Upper panel, representative images. Lower panel: quantification data. Scale bar = 100 μm. (E-F) Effects of pkc-2 RNAi (E) and sgk-1 mutation (F) on let-607 knockdown-induced MTL-1::GFP expression. Left panel, representative images. Right panel: quantification data. Scale bar = 100 μm. (G) Influence of sgk-1 RNAi on the lifespan of WT and let-607 knockdown worms. Data were presented as mean ± SEM. *** p < 0.001.